The presence of the adenine nucleotide translocator in ϱ-yeast mitochondria
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چکیده
منابع مشابه
Adenine Nucleotide Translocator Transports Haem Precursors into Mitochondria
Haem is a prosthetic group for haem proteins, which play an essential role in oxygen transport, respiration, signal transduction, and detoxification. In haem biosynthesis, the haem precursor protoporphyrin IX (PP IX) must be accumulated into the mitochondrial matrix across the inner membrane, but its mechanism is largely unclear. Here we show that adenine nucleotide translocator (ANT), the inne...
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The adenine nucleotide translocator (ANT) spans the inner mitochondrial membrane and facilitates exchange of cytosolic ADP for ATP within the mitochondrial matrix. ANT represents the most prominent single protein component of the inner mitochondrial membrane (1). However, its role in cardiac disease processes and physiology has only recently been a major focus of attention. ANT participates in ...
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The regulatory role of adenine nucleotide translocase in oxidative phosphorylation was determined by titration of respiration of isolated rabbit heart mitochondria with carboxyatractyloside in the creatine phosphokinase ADP-regenerating system, which is not rate-limiting. It was found that the respiration rate is not controlled by adenine nucleotide translocase in states 3 and 4. Within the phy...
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We have previously described a fluorimetric method to measure ADP-ATP exchange rates in mitochondria of permeabilized cells where phosphorylases, kinases, ion pumps exhibiting substantial ATP hydrolase activity and other competing reactions interconverting adenine nucleotides are present. This was achieved by recording changes in free extramitochondrial [Mg] reported by the Mg-sensitive fluores...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1975
ISSN: 0014-5793
DOI: 10.1016/0014-5793(75)80774-5